Cardior is pioneering its proprietary RNA technology to revolutionize predicting and treating heart failure. Impaired myocardial sarcoplasmic reticulum calcium-ATPase 2a SERCA2a activity a system critically involved in intracardial calcium homeostasis is a hallmark of failing hearts. Thereby, his research is extending the translational expertise of the TRAIN Network towards the transfer of research into an application by founding a company and producing a product for patients. For more information, please visit https: This meeting Experimental Biology EB is held annually involving five societies and bringing together more than 12, scientists and 25 guest societies in one interdisciplinary community.
This process has previously been shown to contribute to fibrobla s t formation in fibrotic diseases of t he kidney, lung, liver and the heart. August Myocardial infarction leads to cardiac r emodeling and development of heart failure. This course, regularly organized by ESACT, brings together scientists and PhD students from academia with lab managers from industry and established research institutes. Katharina had already presented her work in the Best Poster Session of the ESC congress in Barcelona further highlighting the relevance of her research. The Leducq Foundation is a French foundation, which has the aim to support international research cooperations between Europe and the United States to create alliances without borders in the sector of cardiovascular diseases. MicroRNA regulates vascularity after myocardial infarction. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome.
Work Group Leaders – REBIRTH Cluster of Excellence
For more information, please visit http: With this award the ESC Council for Basic Diissertation Science annually honours two basic researchers with outstanding accomplishments in the early stage of their career. With more than active participants the meeting was the so far largest meeting of the Working Groups and a great success.
MiR induces endothelial cell apoptosis, abolishes endothelial capillary network formation.
MiRa and miRb levels were significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. Locked nucleic acid-mediated miR silencing ameliorated cardiac fibrosis development in vivo. For more information, please visit www. May Professor Dr. IMTTS identifies a novel therapy for reducing doxorubicin-induced cardiotoxicity.
The findings are published in the journal Circulation Research. Altered cardiac autophagy has been reported in various dizsertation diseases.
September New therapies for conditions such as cardiac hypertrophy and heart failure are needed and may be developed as a result of a better understanding of the tight regulation of gene transcription in heart muscle cells.
Professor Thomas Thum and Dr. Despite the preliminary character of the promising initial data, the results provide rationale for a confirmation study in larger MS cohorts.
Patients were followed for 6 months regarding all-cause mortality. Cardior Pharmaceuticals is a privately held German biotech company pioneering the next generation of non-coding RNA based therapeutics in heart failure.
This international research group will focus on the creation, calcification and morbid expansion of blood vessels. OPN and miR were significantly increased in cardiac biopsies of patients with myocardial fibrosis. In this study we investigated whether the presence of chronic kidney disease CKD modifies the association of LIPCAR plasma levels and left ventricular remodeling and patient outcome. Dangwal will investigate genome wide miRNA profile changes in laser capture isolated dermal cells from skin biopsies of DFU subjects with complete healing vs non healing wounds to study dissertayion depth in-vitro and in-vivo molecular mechanisms of miRNA mediated gene regulation crucial for tissue repair process.
MicroRNA regulates vascularity after myocardial infarction. The current list of Highly Cited Researchers https: Thus, miR could be of therapeutic interest to treat elderly individuals with dissertatino infarction in near future.
Our observation that a microRNA in endothelial cells affects downstream epigenetic pathways leading to impaired angiogenic activity opens new dissertation for using miRNAs as epigenetic modifiers to develop of novel vascular therapeutic strategies.
This year an Excellent Paper was selected for the Cardiovascular Research Award EPCA with the idea to identify excellent work in the field of cardiovascular sciences and to promote young scientists. April Physiological aging dissertatjon senescence are associated to progressive decline in most physiological functions, reduced response to stress, loss of viability and increased susceptibility to various diseases.
Role of long non-coding RNAs as potential Biomarkers in heart disease.
The funded project investigates the functional relevance of a miR cluster in cardiac ischemia. In a next step the IMTTS researchers want to develop Chast inhibitors for humans so that patients with diseased or failing hearts can be treated more successfully in future.
Our studies thus underline the efficiency of modulating miR in cardiac remodelling and failure. The HiLF program supports early career postdocs HiLF I with an initial funding allowing the scientist to generate preliminary data for a successful application for external third party funding. The European researchers will firstly identify biomarker candidates in blood and study their predictive value for heart failure and common co-morbidities associated with ageing renal impairment, cognitive disorders….
For the first time the ESC Scientists of Tomorrow and the HFA Heart Failure Specialists of Tomorrow were invited to create mhg one specific session to increase the visibility also for young active cardiovascular scientists and clinicians.
The study has been published in the European Heart Journal and a link can be found here http: Thomas Thum received 1. These effects are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the pactivated kinase PAK4, which were disertation by bioinformatic predictions and validated by luciferase gene reporter assays.
Both researchers have a budget of about