Pubmed Abstract Pubmed Full Text. Comparison of 1, laparoscopic and open partial nephrectomies for single renal tumors. Am J Clin Pathol 6: Following partial nephrectomy, the PRA and plasma aldosterone levels declined rapidly and the blood pressure and potassium supplementation requirements normalized. Our patient presented with long-standing headaches, followed by the development of lethargy, and polyuria with polydipsia. Examination of the heart revealed normal heart sounds and no murmurs. Further imaging studies were aimed at localizing the source of increased renin production.
Cytogenetic examination of the tumor revealed normal female karyotype 46, XX without any chromosomal abnormalities. Plain radiographs are of limited diagnostic value. Increased production of renin from the affected kidneys causes blood pressure elevation, leading to the development of renin-mediated hypertension. Most neoplastic cells are also diffusely positive for CD34 a vascular marker , an additional marker that can differentiate reninoma from RCC 8. You can login by using one of your existing accounts. Detailed ophthalmologic examination did not reveal any hypertensive changes.
Renal vein renin sampling with lateralization might help to identify the site of excessive renin production.
We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients.
Recurrent hypertensive cerebral hemorrhages in a boy caused by a reninoma: There was no history of nausea, vomiting, syncope, or visual disturbance. Whether these patients eventually become normotensive znd difficult to predict given no reports on long-term follow-up. The subject had persistent elevation of both plasma renin activity PRA and aldosterone.
Reninoma: Case report and literature review
The vessels were dissected and clamped. It is important to remember that these medications affect the production and secretion of RAAS hormones and thus alter the blood levels of these hormones.
Hypertensive crisis in children. A sagittal reformat through the left kidney shows a rounded 10 mm low-attenuation lesion projecting from the extreme periphery of the anterior renal margin, appearing subcapsular in position arrow. J Clin Hypertens Greenwich 14 Chromosomal abnormalities have been ajd in cases of reninoma, with monosomy of chromosome 9, 11, and 15, and polysomy of chromosomes 3, 4, 10 13, 17, and 18 3.
All authors were involved in the care of the patient. The arrows point to litedature cell tumor reninoma.
Reninoma: case report and literature review.
A renin-secreting tumour with severe hypertension and cardiovascular disease: Immunoperoxidase staining for renin was not available. As an excellent means of imaging of the renal vasculature, renal parenchyma, and adrenal glands, we recommended that CTA be considered in all cases of renin-mediated hypertension in children.
Hypertensive target organ damage evaluation revealed normal magnetic resonance imaging MRI of the brain and structurally normal heart. Though significant, the radiation burden associated with CT is justified through a number of advantages over other modalities.
We present our approach to diagnostic evaluation of this patient that led us to the correct diagnosis of reninoma, and discuss the regiew management and surgical treatment of this rare tumor.
Because of the normal appearance of the kidneys, we suspected a renovascular cause of hypertension. Pediatr Nephrol 28 7: Abstract Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin.
Chromosome abnormalities in juxtaglomerular cell tumors. Review of juxtaglomerular cell tumor with focus on pathobiological casf. Plain radiographs are of limited diagnostic value. Case Presentation A year-old girl was referred to our hospital for treatment and investigations of hypertension.
Reninomas are an uncommon but well-described cause of renin-mediated hypertension with about reported cases to date 3. Demonstration of the differential hormone levels between the main renal veins and elevation above systemic hormone levels all above the upper limit of normal confirmed the left kidney tumor as a source of excessive renin production.
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Reninoma: case report and literature review. – PubMed – NCBI
A high aldosterone level with a suppressed level of renin point to the adrenal cause tumor, hyperplasiawhere abnormal autonomous hypersecretion of aldosterone suppresses the secretion of renin by the kidneys.
The tumor cells stain positive for CD The surgical procedure is done either by open or, more commonly, laparoscopic approach The patient was placed in the lateral position with left side up.
Loss of chromosomes 9 and 11 may be recurrent chromosome imbalances in juxtaglomerular cell tumors. Further imaging studies were aimed at localizing the source of increased renin production.
Prevalence of hypertension in children is about 2.